WASHINGTON (AP) — The Latest on the Republican legislation overhauling the Obama health care law (all times EDT):

10:25 a.m.

House Speaker Paul Ryan says he has faith in Senate Majority Leader Mitch McConnell’s ability to round up the votes for the Republican health care bill despite growing opposition in the Senate.

Ryan told reporters on Tuesday: “I would not bet against Mitch McConnell.”

The Wisconsin Republican said he has every expectation that the Senate will move ahead on the bill, which the Congressional Budget Office says would kick 22 million off the insurance rolls. The bill would cut taxes, reduce the deficit and phase out the Medicaid expansion implemented by Barack Obama’s health law.

Ryan said every Republican senator campaigned on repealing and replacing Obama’s law.

The speaker said House members are waiting to see what happens in the Senate. The House could try to vote after the Senate to push the bill and get it to President Donald Trump before the weeklong July 4th recess.

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7:45 a.m.

Senate Republican leaders are scrambling to rescue their health care bill. It’s in trouble as opposition from rebellious Republicans grows.

The defections came as Congress’ nonpartisan budget referee said the measure would leave 22 million more people uninsured by 2026 than President Barack Obama’s law, which Republicans are trying to replace.

Majority Leader Mitch McConnell, R-Ky., was hoping to staunch his party’s rebellion, a day after the Congressional Budget Office released its report. He’s been aiming at winning Senate passage this week, before a weeklong July 4 recess that leaders worry opponents will use to weaken support for the legislation.

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4:02 a.m.

Congress’ nonpartisan budget referee says the Senate Republican health care bill would leave 22 million additional people uninsured in 2026 compared to President Barack Obama’s law.

And now, disgruntled centrist and conservative GOP senators are forcing Senate Majority Leader Mitch McConnell to scramble to rescue the measure before debate even begins.

The Kentucky Republican was hoping to staunch his party’s rebellion on Tuesday, a day after the Congressional Budget Office released its report. He plans to suggest revisions to the legislation in hopes of rounding up votes.

McConnell wants to win Senate passage this week. But three GOP senators are threatening to vote against a procedural motion to begin debate, a vote expected Wednesday. To be approved, no more than two of the 52 GOP senators can vote against it.